Stanford resistance mutation sheet

Frequently updated, the Stanford HIV database posts lists of clinically relevant mutations on its website that can be downloaded. The link is:

http://hivdb.stanford.edu/pages/download/resistanceMutations_handout.pdf

- Christopher Hurt

Viral decay curve

Once you start someone on ARVs, there's a predictable decline in viral load associated with it. This article from Nature Medicine has a nice figure, showing that different cell populations actually give rise to different portions of the decay curve, and as each replication within each "compartment" of cell type gets shut off by ARVs, that population's contribution to the viral load trails off, leading to the curve. (Hopefully it'll make better sense when you look at the figure!)

http://www.nature.com/nm/journal/v9/n7/fig_tab/nm0703-853_F2.html
from (http://www.nature.com/nm/journal/v9/n7/full/nm0703-853.html)

- Christopher Hurt

Super cool HIV interactive graphic

The New England Journal published the studies of raltegravir's use/efficacy for patients with an optimized background regimen (OBR) recently, and it turns out they also had an online-only interactive graphic that would be great for teaching students and residents visiting on the service. It's online at:

http://content.nejm.org/content/vol359/issue4/images/data/339/DC2/AIDS_Interactive.shtml

Enjoy!

– Christopher Hurt, MD